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Drinking alcohol with MDMA or molly is common.

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By David Concar. A WEEKEND dose of the drug Ecstasy can lead to forgetfulness, poor concentration and mid-week blues severe enough to qualify the sufferer for clinical treatment, claim British researchers.

Drugs and alcohol (young people)

The depression suffered by Ecstasy users is deeper, takes several days to surface and lasts longer, she reports in a paper to appear next month in the journalAddiction. In another study, which has not been published, Andrew Parrott and his colleagues at the University of East London and Keith Wesnes of Cognitive Drug Research, a company in Reading that tests the effects of drugs on memory and learning, have evidence of link between memory impairment and Ecstasy.

And a third study, also unpublished, strengthens that link by screening out the effects of other drugs such as LSD, amphetamines and cannabis. Michael Morgan and his colleagues at the University of Wales, Swansea, compared two groups of Welsh drug users with a control group of people the same age.

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The two drug groups matched each other for consumption of most drugs, but only one took Ecstasy. In most tests, the three groups performed similarly, indicating that Ecstasy users are no less intelligent than the norm. But the Ecstasy group performed markedly worse in memory tests. The psychological consequences of taking Ecstasy have been hotly debated for years.

What can be done to counter the effects of an mdma hangover?

Inresearchers in the US tested long-time users and found some evidence of forgetfulness but none of depression. However, that study involved no control subjects and looked only at people who had not taken the drug for two months. Curran addressed that issue by setting up makeshift psychology lab in a London club, helped by research student and part-time DJ Ross Travill.

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On successive Saturday nights, the researchers recruited a dozen clubbers who claimed they had taken Ecstasy that evening and a dozen who said they had only drunk alcohol. Volunteers completed a round of mood and memory tests in the lab at the club, and were tested again at their homes the next day and the following Wednesday.

In the club and the following day, Ecstasy users did almost twice as badly as the alcohol group. By Wednesday, the scores were closer but the alcohol group still did better. But the biggest differences emerged with the mood tests.

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The day after clubbing, those who had stuck to alcohol were just as irritable, depressed and anxious as those who had swallowed Ecstasy. But by Wednesday, the drinkers had snapped out of it while Ecstasy users had slid deeper into depression.

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On average, their mid-week scores for irritability and restlessness were 50 per cent higher and their anxiety ratings double those of the alcohol group. In the study led by Parrott, Ecstasy users proved especially bad at remembering words. In one test, 15 words appeared in middle of a computer screen, one after the other.

Ecstasy use and the following hangover

Afterwards, subjects were told to write down as many as they could remember. Several days after a night out clubbing, regular Ecstasy users typically recalled about 30 per cent fewer words than those who said they had never taken the drug. Some other researchers argue that the new data are inconclusive.

One major flaw is that none of the three teams could be absolutely certain what drugs their subjects had taken, as they did not perform urine tests. Nicholas Saunders, an independent researcher based in London who has written a book about Ecstasy, argues that many of the observed memory problems could be due to cannabis use. The psychologists themselves caution against alarmist interpretations. Why Ecstasy should cause mid-week depression or impair memory is far from clear.

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